Back Pertussis-Toxin German Pertussis toxin English Toxina pertussis Spanish Tossina della pertosse Italian 百日咳毒素 Japanese Toksin oslovskega kašlja Slovenian Pertuzijski toksin Serbian Pertussistoxin Swedish
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| Kristalna struktura pertuzijskog toksina,[1] | |||||||||
| Identifikatori | |||||||||
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| Simbol | Pertussis_S1 | ||||||||
| Pfam | PF02917 | ||||||||
| InterPro | IPR003898 | ||||||||
| SCOP | 1bcp | ||||||||
| Superfamilija | 1bcp | ||||||||
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| Identifikatori | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Simbol | Pertussis_S2S3 | ||||||||
| Pfam | PF02918 | ||||||||
| InterPro | IPR003899 | ||||||||
| SCOP | 1bcp | ||||||||
| Superfamilija | 1bcp | ||||||||
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| Identifikatori | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Simbol | Pertus-S4-tox | ||||||||
| Pfam | PF09275 | ||||||||
| InterPro | IPR015355 | ||||||||
| SCOP | 1prt | ||||||||
| Superfamilija | 1prt | ||||||||
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| Identifikatori | |||||||||
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| Simbol | Pertus-S5-tox | ||||||||
| Pfam | PF09276 | ||||||||
| InterPro | IPR015356 | ||||||||
| SCOP | 1prt | ||||||||
| Superfamilija | 1prt | ||||||||
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Pertuzijski toksin (PT) je proteinski egzotoksin AB5-tipa koji proizvodi bakterija Bordetella pertussis,[2] koja uzrokuje veliki kašalj. PT učestvuje u kolonizaciji respiratornog trakta i uspostavljanju infekcije.[3] Istraživanja sugeriraju da PT možda može da ima terapeutsku ulogu u tretiranju brojnih ljudskih bolesti, među kojima je hipertenzija,[4] viralna inhibicija,[5] i autoimunska inhibicija.[6][7][8]
- ↑ Stein PE, Boodhoo A, Armstrong GD, Cockle SA, Klein MH, Read RJ (January 1994). „The crystal structure of pertussis toxin”. Structure 2 (1): 45-57. DOI:10.1016/S0969-2126(00)00007-1. PMID 8075982.
- ↑ Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th izd.). McGraw Hill. ISBN 0-8385-8529-9.
- ↑ Carbonetti NH, Artamonova GV, Mays RM, Worthington ZE (November 2003). „Pertussis Toxin Plays an Early Role in Respiratory Tract Colonization by Bordetella pertussis”. Infect. Immun. 71 (11): 6358-66. DOI:10.1128/IAI.71.11.6358-6366.2003. PMC 219603. PMID 14573656.
- ↑ Kost C, Herzer W, Li P, Jackson E (1999). „Pertussis toxin-sensitive G-proteins and regulation of blood pressure in the spontaneously hypertensive rat”. Clin Exp Pharmacol Physiol 26 (5–6): 449-55. DOI:10.1046/j.1440-1681.1999.03058.x. PMID 10386237.
- ↑ Alfano M, Pushkarsky T, Poli G, Bukrinsky M (2000). „The B-Oligomer of Pertussis Toxin Inhibits Human Immunodeficiency Virus Type 1 Replication at Multiple Stages”. J Virol 74 (18): 8767-70. DOI:10.1128/JVI.74.18.8767-8770.2000. PMC 116391. PMID 10954581.
- ↑ Bagley K, Abdelwahab S, Tuskan R, Fouts T, Lewis G (2002). „Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cAMP-dependent pathway”. J Leukoc Biol 72 (5): 962-9. PMID 12429718.
- ↑ Locht C, Keith JM (1986). „Pertussis toxin gene: nucleotide sequence and genetic organization”. Science 232 (4755): 1258-1264. DOI:10.1126/science.3704651. PMID 3704651.
- ↑ Rappuoli R, Nicosia A, Perugini M, Franzini C, Casagli MC, Borri MG, Antoni G, Almoni M, Neri P, Ratti G (1986). „Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication”. Proc. Natl. Acad. Sci. U.S.A. 83 (13): 4631-4635. DOI:10.1073/pnas.83.13.4631. PMC 323795. PMID 2873570.
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